The Aureochrome1a LOV domain from Phaeodactylum tricornutum is a flavin-binding blue-light sensory protein domain used as the basis for designed LOV-domain flavoproteins. In the cited 2020 Scientific Reports study, tailored LOV-domain flavoproteins produced nuclear hyperpolarization upon illumination, functioning as light-driven spin machines.
Home/Mechanisms/photo-cidnp
Mechanism Concept
photo-cidnp
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 0 architectures and 2 components. Representative components include Aureochrome1a LOV domain and Mr4511 LOV domain.
2 total items0 architectures2 components
Components
2 of 2Mr4511 is a light-responsive LOV domain from Methylobacterium radiotolerans that has been used as a protein scaffold for engineered flavoprotein spin machines. In designed variants, tryptophan insertion at canonical or novel positions enabled illumination-dependent nuclear hyperpolarization detectable by 15N and 1H liquid-state high-resolution NMR.