opto-PROTAC is a light-inducible PROTAC design in which a photolabile caging group is installed on pomalidomide-based degraders to block activity in the dark and permit target protein degradation after ultraviolet A irradiation. It was demonstrated using caged pomalidomide and the PROTACs dBET1 and dALK to achieve spatiotemporal control of protein destruction.
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Mechanism Concept
photodecaging
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 1 architecture and 0 components. Across those tools, the main enabled capabilities are degradation.
1 total items1 architectures0 components
Main enabled capabilities: degradation.