Here, we introduce an adaptor-based strategy for regulating SynNotch activity via fluorescein isomers and analogs.
Home/Mechanisms/photouncaging
Mechanism Concept
photouncaging
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 4 architectures and 0 components. Across those tools, the main enabled capabilities are signaling and transcription.
4 total items4 architectures0 components
Main enabled capabilities: signaling, transcription.
Architectures
4 of 4fluorescein-conjugated extracellular matrix (ECM)-binding peptides can be used to regulate SynNotch activity depending on the folding state of collagen-based ECM networks
The web research summary states that the anchor paper describes MRS7145 as the first light-dependent adenosine A2A receptor antagonist and identifies it as the photo-controlled/photocaged adenosine A2A receptor antagonist used for light-dependent blockade in cells and behaving animals.
Using an optimized fluorescein-binding SynNotch receptor, we describe ways to chemically control SynNotch signaling...