The TRIM21 RING domain is a catalytic protein domain whose ubiquitination activity is activated by substrate-induced clustering that promotes intermolecular RING dimerization. In the cited 2020 study, this activation mechanism underlies TRIM21-dependent antiviral responses and Trim-Away-mediated protein degradation.
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Mechanism Concept
ubiquitination
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 0 architectures and 1 component. Across those tools, the main enabled capabilities are degradation. Representative components include TRIM21 RING domain.
1 total items0 architectures1 components
Main enabled capabilities: degradation.