Source 1review2020Cell and Tissue Research
Toolkit/CLARITY technology
CLARITY technology
Also known as: CLARITY
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
CLARITY technology ... can be used to visualize ... neuronal circuits in whole-brain samples.
Usefulness & Problems
Why this is useful
CLARITY is described here as a technology used to visualize neuronal circuits in whole-brain samples. The review includes it among the principal methods for CNS investigation.; visualizing neuronal circuits in whole-brain samples; exploring mechanisms underlying CNS disease models; evaluating effects of drugs in neuroscience studies
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CLARITY is described here as a technology used to visualize neuronal circuits in whole-brain samples. The review includes it among the principal methods for CNS investigation.
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visualizing neuronal circuits in whole-brain samples
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exploring mechanisms underlying CNS disease models
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evaluating effects of drugs in neuroscience studies
Problem solved
It helps researchers inspect neuronal circuits across whole-brain samples when studying disease mechanisms and drug effects.; enables whole-brain sample visualization of neuronal circuits
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It helps researchers inspect neuronal circuits across whole-brain samples when studying disease mechanisms and drug effects.
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enables whole-brain sample visualization of neuronal circuits
Problem links
enables whole-brain sample visualization of neuronal circuits
LiteratureIt helps researchers inspect neuronal circuits across whole-brain samples when studying disease mechanisms and drug effects.
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It helps researchers inspect neuronal circuits across whole-brain samples when studying disease mechanisms and drug effects.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
light-based visualizationTechniques
Functional AssayTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: sensor
The abstract supports the need for whole-brain samples and CLARITY-compatible processing. It does not provide the clearing, labeling, or imaging details in the supplied evidence.; requires whole-brain sample preparation compatible with CLARITY
The abstract does not state that CLARITY is the method for visualizing small molecules in brain tissue or the interstitial system of the brain.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
These reviewed tools serve as powerful technical means to explore mechanisms underlying disease models and to evaluate drug effects in neuroscience.
CLARITY technology and optogenetics can be used to visualize neuronal circuits in whole-brain samples.
Tracer-based magnetic resonance imaging can be used to visualize the interstitial system of the brain.
The review covers MALDI time-of-flight mass spectrometry imaging, tracer-based MRI, CLARITY technology, and optogenetics as CNS study tools.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug clarity-technology
CLARITY technology ... can be used to visualize ... neuronal circuits in whole-brain samples.
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application summarysupports
These reviewed tools serve as powerful technical means to explore mechanisms underlying disease models and to evaluate drug effects in neuroscience.
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capability summarysupports
CLARITY technology and optogenetics can be used to visualize neuronal circuits in whole-brain samples.
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review scope summarysupports
The review covers MALDI time-of-flight mass spectrometry imaging, tracer-based MRI, CLARITY technology, and optogenetics as CNS study tools.
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Comparisons
Source-stated alternatives
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
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Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Source-backed strengths
presented as a powerful technical means for neuroscience studies
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presented as a powerful technical means for neuroscience studies
Compared with imaging
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
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Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Compared with imaging surveillance
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
Source:
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Compared with mass spectrometry
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
Source:
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Compared with optogenetic functional interrogation
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
Source:
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Compared with optogenetic membrane potential perturbation
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
Source:
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Compared with Tracer-based magnetic resonance imaging
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: presented as a powerful technical means for neuroscience studies.
Source:
Other approaches named in the review are MALDI mass spectrometry imaging, tracer-based MRI, and optogenetics.
Ranked Citations
- 1.