Source 1primary paper2018Cell Reports
Toolkit/directional reaching for water behavioral framework
directional reaching for water behavioral framework
Also known as: directional reaching for water, head-fixed mouse directional reaching task, mouse center-out reaching task
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The directional reaching for water behavioral framework is a head-fixed mouse assay in which animals make center-out-like reaches toward water droplets presented at multiple spatial locations. It enables structured study of cortex-dependent reaching, sensorimotor processing, and decision making, and has been used with optogenetic motor cortex inactivation.
Usefulness & Problems
Why this is useful
This framework provides a primate-like directional reaching paradigm in mice, addressing the need for structured motor behavior assays that can be paired with modern neural recording and perturbation methods. Source evidence indicates that mice can perform vibratotactile-instructed directional reaches, supporting its use for studying motor control, sensory processing, and decision making.
Source:
This framework trains head-fixed mice to directionally reach for water droplets in a task analogous to the primate center-out reaching paradigm. It supports repeated reaches to multiple target locations.
Source:
studying motor control in mice
Source:
studying sensory processing in mice
Source:
studying decision making in mice
Problem solved
It helps solve the lack of mouse behavioral paradigms analogous to the primate center-out reaching task for probing goal-directed forelimb movements. The assay offers a reproducible head-fixed reaching structure that can support causal interrogation of motor cortex function during movement initiation and execution.
Source:
It addresses the lack of primate-like mouse behavioral paradigms that can better leverage modern neural recording and manipulation tools. The task provides a structured reaching assay for motor and sensorimotor studies.
Source:
provides a mouse behavioral paradigm more analogous to primate center-out reaching tasks
Source:
enables many repeated directional reaching trials in head-fixed mice
Problem links
enables many repeated directional reaching trials in head-fixed mice
LiteratureIt addresses the lack of primate-like mouse behavioral paradigms that can better leverage modern neural recording and manipulation tools. The task provides a structured reaching assay for motor and sensorimotor studies.
Source:
It addresses the lack of primate-like mouse behavioral paradigms that can better leverage modern neural recording and manipulation tools. The task provides a structured reaching assay for motor and sensorimotor studies.
provides a mouse behavioral paradigm more analogous to primate center-out reaching tasks
LiteratureIt addresses the lack of primate-like mouse behavioral paradigms that can better leverage modern neural recording and manipulation tools. The task provides a structured reaching assay for motor and sensorimotor studies.
Source:
It addresses the lack of primate-like mouse behavioral paradigms that can better leverage modern neural recording and manipulation tools. The task provides a structured reaching assay for motor and sensorimotor studies.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
behavioral sensorimotor instruction by vibratotactile cuesbehavioral sensorimotor instruction by vibratotactile cuesoptogenetic inactivationoptogenetic inactivationTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
behavioral paradigm: Truecofactor dependency: cofactor requirement unknownencoding mode: genetically encodedhead fixed: Trueimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementmulti directional: Trueoperating role: sensortrial throughput text: hundreds of trials
The framework requires head-fixed mice and presentation of water droplets at different spatial target locations. Reported use includes vibratotactile instruction and compatibility with optogenetic motor cortex inactivation; the extraction notes compatibility with layer 2/3 two-photon imaging, but no further construct or hardware details are provided in the supplied evidence.
Available evidence is limited to a single cited study and does not establish independent replication. The extracted explanation notes that water-droplet detection can rely on chemosensation, so the assay does not purely isolate visually guided or abstract target detection; no evidence here addresses use in freely moving mice.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
fraction of reach related neurons with direction selectivity most
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
trial count hundreds of trials
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
Approval Evidence
1 source6 linked approval claimsfirst-pass slug directional-reaching-for-water-behavioral-framework
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
Source:
application scopesupports
Mice could perform directional reaching instructed by vibratotactile stimuli, supporting the framework's use for studying motor control, sensory processing, and decision making.
Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Source:
causal perturbation resultsupports
Optogenetic inactivation of the motor cortex halted movement initiation and rapidly diverted the trajectory of ongoing reaching movements.
Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements.
Source:
mechanistic observationsupports
Mice used chemosensation to determine the presence of water droplets in the task.
Surprisingly, mice used chemosensation to determine the presence of water droplets.
Source:
neural activity observationsupports
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons.
Source:
performancesupports
Mice rapidly engaged in the directional reaching task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations.
Source:
tool introductionsupports
The paper presents a behavioral framework in which head-fixed mice directionally reach for water droplets in a task similar to the primate center-out reaching task.
Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task.
Source:
Comparisons
Source-stated alternatives
The source explicitly contrasts this framework with existing mouse behavioral paradigms that lag behind those of primates. It is presented as analogous to the primate center-out reaching task.
Source:
The source explicitly contrasts this framework with existing mouse behavioral paradigms that lag behind those of primates. It is presented as analogous to the primate center-out reaching task.
Source-backed strengths
The task is explicitly described as analogous to the primate center-out reaching task while being implemented in mice. Evidence shows that mice can perform directional reaching instructed by vibratotactile stimuli, and optogenetic motor cortex inactivation halted movement initiation and rapidly diverted ongoing reach trajectories, demonstrating sensitivity to causal circuit perturbation.
Source:
mice rapidly engaged in the task
Source:
supports hundreds of trials
Source:
supports reaching in multiple directions
Source:
compatible with optogenetic inactivation and two-photon imaging
Compared with native green gel system
directional reaching for water behavioral framework and native green gel system address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with open-source microplate reader
directional reaching for water behavioral framework and open-source microplate reader address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with plant transcriptome profiling
directional reaching for water behavioral framework and plant transcriptome profiling address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
- 1.