Source 1primary paper2015Scientific Reports
Toolkit/electroencephalography
electroencephalography
Also known as: EEG
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The source lead states that the paper used EEG/SEP readouts.
Usefulness & Problems
Why this is useful
EEG is used here to detect the lateralized periodic discharges that form a central observation of the case. In this report, it provided the electrophysiologic evidence for the abnormal pattern.; detecting lateralized periodic discharges; recognizing seizure-associated electrophysiologic patterns; EEG served as an explicit readout in the reported human focused-ultrasound study. It was used alongside somatosensory evoked potentials according to the source summary.; electrophysiology readout during human tFUS neuromodulation
Source:
EEG is used here to detect the lateralized periodic discharges that form a central observation of the case. In this report, it provided the electrophysiologic evidence for the abnormal pattern.
Source:
detecting lateralized periodic discharges
Source:
recognizing seizure-associated electrophysiologic patterns
Source:
EEG served as an explicit readout in the reported human focused-ultrasound study. It was used alongside somatosensory evoked potentials according to the source summary.
Source:
electrophysiology readout during human tFUS neuromodulation
Problem solved
It helps identify and characterize the abnormal electrical pattern associated with the infant's seizures and myoclonus.; identifies abnormal brain electrical activity associated with seizures and myoclonus in the reported case; It provides a noninvasive electrophysiological measurement channel for assessing responses during human cortical stimulation.; provides a reported measurement readout for stimulation effects
Source:
It helps identify and characterize the abnormal electrical pattern associated with the infant's seizures and myoclonus.
Source:
identifies abnormal brain electrical activity associated with seizures and myoclonus in the reported case
Source:
It provides a noninvasive electrophysiological measurement channel for assessing responses during human cortical stimulation.
Source:
provides a reported measurement readout for stimulation effects
Problem links
identifies abnormal brain electrical activity associated with seizures and myoclonus in the reported case
LiteratureIt helps identify and characterize the abnormal electrical pattern associated with the infant's seizures and myoclonus.
Source:
It helps identify and characterize the abnormal electrical pattern associated with the infant's seizures and myoclonus.
provides a reported measurement readout for stimulation effects
LiteratureIt provides a noninvasive electrophysiological measurement channel for assessing responses during human cortical stimulation.
Source:
It provides a noninvasive electrophysiological measurement channel for assessing responses during human cortical stimulation.
Published Workflows
Objective: To noninvasively stimulate the human primary somatosensory cortex using image-guided transcranial focused ultrasound and assess responses with electrophysiological readouts.
Why it works: The provided source summary indicates that image guidance was used to target the cortical region and electrophysiological readouts were used to detect stimulation-related responses.
stimulation of human primary somatosensory cortexMRI/CT-guided targetingEEG readoutsomatosensory evoked potential readout
Stages
- 1.Image-guided targeting(functional_characterization)
The source summary explicitly states that MRI/CT guidance was used for targeting before electrophysiological readout.
Selection: MRI/CT-guided localization of the human primary somatosensory cortex for transcranial focused ultrasound application
- 2.Electrophysiological response assessment(confirmatory_validation)
The source summary explicitly identifies EEG and SEP as readouts used to assess the stimulation paradigm.
Selection: EEG and somatosensory evoked potential readouts after focused ultrasound stimulation
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
electrophysiological recordingTechniques
Functional AssayTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: payload burdenoperating role: sensor
It requires EEG recording equipment and clinical interpretation of waveform patterns.; requires EEG instrumentation and interpretation; The method requires EEG recording hardware and the stimulation paradigm used in the study. No further protocol detail is provided in the payload.; requires EEG recording during the stimulation paradigm
It does not by itself identify the underlying causal variant or establish the molecular mechanism.; the abstract does not indicate that EEG alone determines genetic causality; The provided evidence does not show that EEG alone localizes the acoustic target or establishes mechanism.; the provided evidence does not specify exact EEG endpoints or performance metrics
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2025MED
Ranked Claims
EEG was used to identify lateralized periodic discharges with a triphasic wave pattern in the reported infant.
Whole exome sequencing identified NPHS1 and PLEKHG2 variants in the reported infant.
Image-guided transcranial focused ultrasound stimulates the human primary somatosensory cortex.
Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex
The reported transcranial focused ultrasound setup used a 250 kHz pulsed transducer.
using MRI/CT-guided targeting, EEG/SEP readouts, and a 250 kHz pulsed transducer
transducer frequency 250 kHz
The study used EEG and somatosensory evoked potentials as readouts for image-guided transcranial focused ultrasound stimulation of human primary somatosensory cortex.
using MRI/CT-guided targeting, EEG/SEP readouts, and a 250 kHz pulsed transducer
Approval Evidence
2 sources2 linked approval claimsfirst-pass slug electroencephalography
Electroencephalography (EEG) revealed lateralized periodic discharges (LPDs), characterized by a triphasic wave pattern.
Source:
The source lead states that the paper used EEG/SEP readouts.
Source:
assay usesupports
EEG was used to identify lateralized periodic discharges with a triphasic wave pattern in the reported infant.
Source:
measurement setupsupports
The study used EEG and somatosensory evoked potentials as readouts for image-guided transcranial focused ultrasound stimulation of human primary somatosensory cortex.
using MRI/CT-guided targeting, EEG/SEP readouts, and a 250 kHz pulsed transducer
Source:
Comparisons
Source-stated alternatives
The abstract does not name alternative neurophysiology assays.; The source materials also mention somatosensory evoked potentials as a paired readout in this study.
Source:
The abstract does not name alternative neurophysiology assays.
Source:
The source materials also mention somatosensory evoked potentials as a paired readout in this study.
Source-backed strengths
directly revealed the key phenotype emphasized by the paper; explicitly used in the anchor study
Source:
directly revealed the key phenotype emphasized by the paper
Source:
explicitly used in the anchor study
Compared with assays
The abstract does not name alternative neurophysiology assays.
Shared frame: source-stated alternative in extracted literature
Strengths here: directly revealed the key phenotype emphasized by the paper; explicitly used in the anchor study.
Relative tradeoffs: the abstract does not indicate that EEG alone determines genetic causality; the provided evidence does not specify exact EEG endpoints or performance metrics.
Source:
The abstract does not name alternative neurophysiology assays.
Compared with somatosensory evoked potentials
The source materials also mention somatosensory evoked potentials as a paired readout in this study.
Shared frame: source-stated alternative in extracted literature
Strengths here: directly revealed the key phenotype emphasized by the paper; explicitly used in the anchor study.
Relative tradeoffs: the abstract does not indicate that EEG alone determines genetic causality; the provided evidence does not specify exact EEG endpoints or performance metrics.
Source:
The source materials also mention somatosensory evoked potentials as a paired readout in this study.
Ranked Citations
- 1.
- 2.