Source 1primary paper2018Investigative Ophthalmology & Visual Science
Toolkit/OMR assay
OMR assay
Also known as: optomotor assay
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The OMR assay, also termed the optomotor assay, is a light-based functional assay used in TKO mice to quantify the efficacy of optogenetic tools for vision restoration. It measures properties of optogenetically restored vision through behavioral optomotor response assessment.
Usefulness & Problems
Why this is useful
This assay is useful because it provides a quantitative format for comparing different optogenetic vision restoration tools in vivo. The cited study further states that it can serve as a valuable tool for developing effective optogenetic therapies.
Problem solved
The assay addresses the need for a robust quantitative method to evaluate and compare optogenetic interventions intended to restore vision. Specifically, it enables assessment of both tool efficacy and the properties of restored visual function in TKO mice.
Problem links
Need precise spatiotemporal control with light input
DerivedThe OMR assay, also termed the optomotor assay, is a light-based functional assay used with TKO mice to quantitatively assess the efficacy of optogenetic tools for vision restoration. It measures properties of optogenetically restored vision in a format reported as robust for comparative evaluation.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
behavioral optomotor response measurementbehavioral optomotor response measurementlight-evoked functional assessmentlight-evoked functional assessmentTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: sensor
The supplied evidence indicates that the assay is performed using TKO mice and relies on light-driven assessment of behavioral optomotor responses. No additional details are provided here regarding stimulus design, hardware, analysis pipeline, or construct delivery requirements.
The provided evidence is limited to a single cited study and does not specify assay parameters, dynamic range, sensitivity, or performance across multiple models. No independent replication, benchmarking against other visual assays, or detailed failure modes are described in the supplied material.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug omr-assay
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
Source:
enables quantitative assessmentsupports
The OMR assay using TKO mice enabled quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
The OMR assay using TKO mice enabled the quantitative assessment of the efficacy of different optogenetic tools and the properties of optogenetically restored vision.
Source:
supports therapy developmentsupports
The assay can serve as a valuable tool for developing effective optogenetic therapies.
Thus, the assay can serve as a valuable tool for developing effective optogenetic therapies.
Source:
Comparisons
Source-backed strengths
Reported strengths are its quantitative readout and its use for comparative evaluation of different optogenetic tools. The available evidence describes the assay as robust for assessing efficacy and properties of optogenetically restored vision.
Compared with native green gel system
OMR assay and native green gel system address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with open-source microplate reader
OMR assay and open-source microplate reader address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with plant transcriptome profiling
OMR assay and plant transcriptome profiling address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
- 1.