Source 1review2014ILAR Journal
Toolkit/social defeat paradigm
social defeat paradigm
Also known as: social defeat
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
Usefulness & Problems
Why this is useful
The social defeat paradigm is presented as an animal model used to study depression-relevant behavior and underlying neurobiology. The review frames it as a way to connect stress exposure with behavioral correlates of depression.; modeling depression-relevant states in animals; investigating possible causes of depression; evaluating possible future therapies
Source:
The social defeat paradigm is presented as an animal model used to study depression-relevant behavior and underlying neurobiology. The review frames it as a way to connect stress exposure with behavioral correlates of depression.
Source:
modeling depression-relevant states in animals
Source:
investigating possible causes of depression
Source:
evaluating possible future therapies
Problem solved
It gives researchers a tractable experimental model for investigating possible causes and treatments of depression. The review positions it as a bridge between animal experimentation and human depression-related questions.; provides an animal model for studying human depression-related phenotypes
Source:
It gives researchers a tractable experimental model for investigating possible causes and treatments of depression. The review positions it as a bridge between animal experimentation and human depression-related questions.
Source:
provides an animal model for studying human depression-related phenotypes
Problem links
provides an animal model for studying human depression-related phenotypes
LiteratureIt gives researchers a tractable experimental model for investigating possible causes and treatments of depression. The review positions it as a bridge between animal experimentation and human depression-related questions.
Source:
It gives researchers a tractable experimental model for investigating possible causes and treatments of depression. The review positions it as a bridge between animal experimentation and human depression-related questions.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Techniques
Functional AssayTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
It requires an animal-model setting in which social defeat can be implemented and behavioral outcomes can be observed. The abstract does not specify species, apparatus, or exact assay components.; requires use of an animal model
The abstract does not claim that the model fully captures the etiologies of human depression or that current treatments are wholly effective within it. It is presented as a possible model, not a definitive one.; described only as a possible model rather than a complete representation of human depression
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The review discusses behavioral correlates to depression and potential underlying neurobiological mechanisms in the social defeat paradigm.
We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
The review presents social defeat as a possible animal model for human depression.
We describe an animal model of social defeat as a possible model for human depression.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug social-defeat-paradigm
We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
Source:
review scope summarysupports
The review discusses behavioral correlates to depression and potential underlying neurobiological mechanisms in the social defeat paradigm.
We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
Source:
review scope summarysupports
The review presents social defeat as a possible animal model for human depression.
We describe an animal model of social defeat as a possible model for human depression.
Source:
Comparisons
Source-stated alternatives
The abstract refers broadly to animal models as tools for investigating human disease, implying that social defeat is one such model among others. No specific alternative depression models are named in the provided text.
Source:
The abstract refers broadly to animal models as tools for investigating human disease, implying that social defeat is one such model among others. No specific alternative depression models are named in the provided text.
Source-backed strengths
presented as a possible model for human depression; supports discussion of behavioral correlates and neurobiological mechanisms
Source:
presented as a possible model for human depression
Source:
supports discussion of behavioral correlates and neurobiological mechanisms
Compared with Langendorff perfused heart electrical recordings
social defeat paradigm and Langendorff perfused heart electrical recordings address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with native green gel system
social defeat paradigm and native green gel system address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
social defeat paradigm and sub-picosecond pump-probe analysis of bacteriorhodopsin pigments address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Ranked Citations