Source 1primary paper2020Crystals
Toolkit/tip-enhanced Raman spectroscopy
tip-enhanced Raman spectroscopy
Also known as: TERS
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Physical background and biomedical applications of spontaneous, stimulated, resonant, and surface- and tip-enhanced RS are also discussed.
Usefulness & Problems
Why this is useful
Tip-enhanced Raman spectroscopy is listed as one of the Raman modalities discussed in the review.; biomedical applications
Source:
Tip-enhanced Raman spectroscopy is listed as one of the Raman modalities discussed in the review.
Source:
biomedical applications
Problem solved
Coherent anti-Stokes Raman scattering can detect and image membrane protein microcrystals for structure-based drug design and protein structural crystallography. Structural studies of photoactive membrane proteins are relevant to development of new optogenetic tools.
Source:
Coherent anti-Stokes Raman scattering can detect and image membrane protein microcrystals for structure-based drug design and protein structural crystallography.
Source:
Structural studies of photoactive membrane proteins are relevant to development of new optogenetic tools.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Techniques
Functional AssayTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
Operational role: sensor. Implementation mode: genetically encoded. Cofactor status: cofactor requirement unknown.
Independent follow-up evidence is still limited. Validation breadth across biological contexts is still narrow. Independent reuse still looks limited, so the evidence base may be fragile. No canonical validation observations are stored yet, so context-specific performance remains under-specified.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Coherent anti-Stokes Raman scattering can detect and image membrane protein microcrystals for structure-based drug design and protein structural crystallography.
Structural studies of photoactive membrane proteins are relevant to development of new optogenetic tools.
Raman spectroscopy is a powerful method linking fundamental structural biology to medical applications.
Spontaneous, stimulated, resonant, surface-enhanced, and tip-enhanced Raman spectroscopy have biomedical applications.
Approval Evidence
1 source1 linked approval claimfirst-pass slug tip-enhanced-raman-spectroscopy
Physical background and biomedical applications of spontaneous, stimulated, resonant, and surface- and tip-enhanced RS are also discussed.
Source:
scopesupports
Spontaneous, stimulated, resonant, surface-enhanced, and tip-enhanced Raman spectroscopy have biomedical applications.
Source:
Comparisons
Source-backed strengths
Physical background and biomedical applications of spontaneous, stimulated, resonant, and surface- and tip-enhanced RS are also discussed.
Compared with Langendorff perfused heart electrical recordings
tip-enhanced Raman spectroscopy and Langendorff perfused heart electrical recordings address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with native green gel system
tip-enhanced Raman spectroscopy and native green gel system address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
tip-enhanced Raman spectroscopy and sub-picosecond pump-probe analysis of bacteriorhodopsin pigments address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Ranked Citations
- 1.