Source 1primary paper2019Nature Communications
Toolkit/UV light-activatable immunostimulatory agent
UV light-activatable immunostimulatory agent
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The UV light-activatable immunostimulatory agent is a rationally designed component of an upconversion nanoparticle-based immunodevice for optical control of antitumor immunity. In the reported system, the agent is activated by UV light, and coupling to an upconversion nanoparticle shifts effective triggering into the near-infrared window for remote activation in vitro and in vivo.
Usefulness & Problems
Why this is useful
This construct is useful for spatially selective immune regulation using light, enabling antitumor immune activation at tumor sites while limiting immune disturbance elsewhere. The reported device supports remote near-infrared control, which addresses the challenge of externally triggering a UV-responsive immunostimulatory component in biological settings.
Source:
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
Problem solved
It helps solve the problem of achieving localized, externally controllable antitumor immune stimulation without broad systemic immune activation. The associated immunodevice was reported to maintain antitumor efficacy while mitigating systemic toxicity through controlled immune regulation.
Problem links
Need precise spatiotemporal control with light input
DerivedThe UV light-activatable immunostimulatory agent is a rationally designed component of an upconversion nanoparticle-based immunodevice for optical control of antitumor immunity. In the reported system, the agent is activated by UV light, and coupling to an upconversion nanoparticle shifts effective triggering into the near-infrared window for remote activation in vitro and in vivo.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
photoactivationspatially selective immune stimulationupconversion-mediated wavelength conversionTechniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
The reported construct is implemented as part of an immunodevice composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle. Practical use depends on coupling the UV-responsive agent to the upconversion nanoparticle so that device light sensitivity is shifted to the near-infrared window; no further construct, formulation, or expression details are provided in the supplied evidence.
The supplied evidence does not identify the molecular identity, target pathway, or photochemical design of the UV-activatable immunostimulatory agent itself. Evidence is limited to a single 2019 study description, so independent replication and broader validation are not established here.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Approval Evidence
1 source1 linked approval claimfirst-pass slug uv-light-activatable-immunostimulatory-agent
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle
Source:
compositionsupports
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
Source:
Comparisons
Source-backed strengths
The reported immunodevice enabled remote control of antitumor immunity with near-infrared light in vitro and in vivo. It was also described as allowing effective immune responses within tumors without disturbing immunity elsewhere, indicating spatial selectivity and reduced systemic toxicity in the reported study.
Compared with Boolean logic gate
UV light-activatable immunostimulatory agent and Boolean logic gate address a similar problem space.
Shared frame: same top-level item type; shared mechanisms: photoactivation; same primary input modality: light
Compared with optogenetic probes
UV light-activatable immunostimulatory agent and optogenetic probes address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with tube-in-tube structure
UV light-activatable immunostimulatory agent and tube-in-tube structure address a similar problem space.
Shared frame: same top-level item type; shared mechanisms: photoactivation; same primary input modality: light
Ranked Citations
- 1.