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Mechanism Concept

caging

A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 0 architectures and 1 component. Representative components include circularly permuted AsLOV2.

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circularly permuted AsLOV2

Circularly permuted AsLOV2 is a re-engineered LOV-domain optogenetic module created by circular permutation of AsLOV2 to enable photoswitchable control over the C-terminus of a peptide. It is reported to function as a light-responsive caging element either alone or in combination with the original AsLOV2 for enhanced caging.