OptoMYPT is a blue-light-controlled multi-component optogenetic switch that couples the PP1c-binding domain of MYPT1 to an optogenetic dimerizer to recruit endogenous protein phosphatase 1c to the plasma membrane. This recruitment induces dephosphorylation of myosin regulatory light chains and reduces actomyosin contractile force.
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Mechanism Concept
dephosphorylation
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 1 architecture and 0 components. Across those tools, the main enabled capabilities are localization and recombination.
1 total items1 architectures0 components
Main enabled capabilities: localization, recombination.