Source 1review2020Advanced Science
Toolkit/NIR light-based imaging
NIR light-based imaging
Also known as: optical imaging
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
NIR light-based imaging is an optical assay and photoregulation approach that uses near-infrared light to sense, and in some cases modulate, specific cellular events in living systems. The cited review describes these strategies as enabling real-time interrogation of deep tissues with subcellular accuracy.
Usefulness & Problems
Why this is useful
This approach is useful for monitoring and potentially controlling cell functions in living systems where deep-tissue access and real-time readout are important. The cited review places its applications in cancer theranostics, regenerative medicine, and neuroscience research.
Source:
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
Source:
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
Problem solved
NIR light-based imaging helps address the challenge of sensing or modulating specific cellular events in deep tissues while retaining subcellular accuracy. The supplied evidence does not provide more specific examples of the cellular events or assay formats involved.
Source:
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
Source:
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
Problem links
This item directly targets deep-tissue optical sensing by using NIR light, which is specifically described as enabling real-time sensing or modulation in deep tissues. That is a close mechanistic match to the gap of tissue scattering limiting optical access.
The summary explicitly states real-time sensing in deep tissues with subcellular accuracy, which is closely aligned to imaging molecules in native 3D contexts. NIR approaches are plausibly relevant where tissue penetration is a core bottleneck.
The gap is about reducing damage during deep live-cell imaging, and this item is explicitly framed as an imaging strategy for deep tissues with real-time sensing. NIR excitation is plausibly relevant to lowering phototoxicity and improving penetration compared with shorter-wavelength approaches, though the summary does not directly document reduced destructiveness or nanoscale resolution.
This item is directly framed as a real-time imaging approach for sensing specific cellular events in deep tissues, which aligns with the gap's need for improved access to living brain state information. Its NIR basis plausibly supports deeper tissue access than visible-light methods, though the evidence provided does not establish human-brain use.
We Can’t Take High-Resolution Movies of or Intervene in Brain Computation at the Single Neuron Level
Gap mapView gapThis item is directly framed as real-time imaging in deep tissues with subcellular accuracy, which is mechanistically aligned with the imaging side of the gap. Deep-tissue compatibility is relevant for in vivo brain observation, although single-neuron network movies are not demonstrated in the supplied evidence.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Target processes
translationInput: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknowndomain: epilepsy researchencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementmodality: optical recordingoperating role: sensorrole: paired imaging modality
Implementation is based on near-infrared light as the input modality for imaging and photoregulation in living systems. The provided evidence does not specify construct design, cofactors, instrumentation parameters, or delivery methods.
The supplied evidence is limited to high-level review statements and does not specify particular probes, wavelengths, molecular targets, or quantitative performance metrics. Independent experimental replication, comparative benchmarking, and implementation constraints are not described in the provided material.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2018Journal of Neural Engineering
Source 3review2021The Neuroscientist
Source 4review2013Philosophical Transactions of the Royal Society B Biological Sciences
Ranked Claims
Combining optical stimulation with optical imaging or high-field functional magnetic resonance imaging adds high value for translation to clinical practice.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
Recent advances in optical imaging, optogenetics, and chemogenetics have made it feasible to record and alter neuronal activity with single neuron resolution and genetically directed targeting.
Recent advances in optical imaging, optogenetics, and chemogenetics have made it feasible to record and alter neuronal activity with single neuron resolution and genetically directed targeting.
The review proposes a translational pathway by which mechanistic studies using these research tools could result in novel clinical therapies.
The goal of this review it to summarize the usage of these research tools in the study of ictogenesis (seizure generation) and propose a translational pathway by which these studies could result in novel clinical therapies.
The review concludes that evidence from optical imaging, molecular-genetic, and optogenetic techniques together with behavioural analyses continues to support the idea that changing the strength of connections between neurons is one of the major mechanisms by which engrams are stored in the brain.
Approval Evidence
4 sources6 linked approval claimsfirst-pass slugs nir-light-based-imaging, optical-imaging
When combined with other methods like optical imaging and high-field functional magnetic resonance imaging, the translation of optical stimulation to clinical practice adds high value.
Source:
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
Source:
Recent advances in optical imaging, optogenetics, and chemogenetics have made it feasible to record and alter neuronal activity with single neuron resolution and genetically directed targeting.
Source:
Evidence derived using optical imaging, molecular-genetic and optogenetic techniques in conjunction with appropriate behavioural analyses continues to offer support
Source:
translational valuesupports
Combining optical stimulation with optical imaging or high-field functional magnetic resonance imaging adds high value for translation to clinical practice.
Source:
application domainsupports
The review states that NIR light-based techniques have applications in cancer theranostics, regenerative medicine, and neuroscience research.
In particular, the applications of NIR light-based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed.
Source:
application scopesupports
NIR light-based imaging and photoregulation strategies are described as enabling real-time sensing or modulation of specific cellular events in deep tissues with subcellular accuracy.
Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy.
Source:
review summarysupports
Recent advances in optical imaging, optogenetics, and chemogenetics have made it feasible to record and alter neuronal activity with single neuron resolution and genetically directed targeting.
Recent advances in optical imaging, optogenetics, and chemogenetics have made it feasible to record and alter neuronal activity with single neuron resolution and genetically directed targeting.
Source:
translational pathwaysupports
The review proposes a translational pathway by which mechanistic studies using these research tools could result in novel clinical therapies.
The goal of this review it to summarize the usage of these research tools in the study of ictogenesis (seizure generation) and propose a translational pathway by which these studies could result in novel clinical therapies.
Source:
review conclusionsupports
The review concludes that evidence from optical imaging, molecular-genetic, and optogenetic techniques together with behavioural analyses continues to support the idea that changing the strength of connections between neurons is one of the major mechanisms by which engrams are stored in the brain.
Source:
Comparisons
Source-backed strengths
According to the cited review, these strategies support real-time sensing and/or modulation of cellular events in deep tissues with subcellular accuracy. The evidence also indicates relevance across multiple biomedical domains, including cancer theranostics, regenerative medicine, and neuroscience.
Compared with native green gel system
NIR light-based imaging and native green gel system address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with open-source microplate reader
NIR light-based imaging and open-source microplate reader address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with plant transcriptome profiling
NIR light-based imaging and plant transcriptome profiling address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
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